作者
Francesco Patti, Alessandra Nicoletti, A Pappalardo, A Castiglione, S Lo Fermo, S Messina, E D’Amico, V Cimino, Mario Zappia
发表日期
2012/2
期刊
Acta neurologica scandinavica
卷号
125
期号
2
页码范围
91-95
出版商
Blackwell Publishing Ltd
简介
Patti F, Nicoletti A, Pappalardo A, Castiglione A, Lo Fermo S, Messina S, D’Amico E, Cimino V, Zappia M. Frequency and severity of headache is worsened by Interferon‐β therapy in patients with multiple sclerosis.
Acta Neurol Scand: 2012: 125: 91–95.
© 2011 John Wiley & Sons A/S.
Background – The relationship between multiple sclerosis (MS) and headache (HA) is not well known. It was reported that interferon‐beta (IFNβ) could induce or worsen HA.
Objective – To evaluate the impact of IFNβ treatment on HA and the relationship between HA and the various commercial preparations of IFNβ in mildly disabled patients with MS.
Methods – A specific questionnaire was administered to 357 relapsing‐remitting MS patients. Characteristics of HAs were considered, including the temporal relationships with IFNβ administration.
Results – One hundred and seventeen patients were treated with weekly …
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F Patti, A Nicoletti, A Pappalardo, A Castiglione… - Acta neurologica scandinavica, 2012