作者
Susanna Asseyer, Josh Hamblin, Silvia Messina, Romina Mariano, Nadja Siebert, Rosie Everett, Wilhelm Küker, Judith Bellmann-Strobl, Klemens Ruprecht, Sven Jarius, Maria Isabel Leite, Alexander U Brandt, Friedemann Paul, Jacqueline Palace
发表日期
2020/5/1
期刊
Multiple sclerosis and related disorders
卷号
40
页码范围
101965
出版商
Elsevier
简介
Background
Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease is an inflammatory autoimmune condition of the central nervous system, defined by antibodies (Abs) against MOG. Of the various clinical phenotypes optic neuritis (ON) is the commonest. We have observed that some patients with MOG-Ab ON present with a severe associated headache.
Objective
To highlight the importance of headache in MOG-Ab related optic neuritis.
Methods
Clinical and MRI data from MOG-Ab patients with ON (n = 129) were obtained from observational cohort studies and clinical notes at the NeuroCure Clinical Research Center, Charité Berlin and at the Diagnostic and Advisory Service for Neuromyelitis Optica, John Radcliffe Hospital, Oxford.
Results
Sixty-four of 129 MOG-Ab patients (49.6%) reported ≥1 headache-related ON. Headache usually started a few days prior to visual loss and extended from the ocular …
引用总数
2020202120222023202461015183
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