作者
Xiaozhe Yang, Tong Zhao, Lin Feng, Yanfeng Shi, Jinjin Jiang, Shuang Liang, Baiyang Sun, Qing Xu, Junchao Duan, Zhiwei Sun
发表日期
2019/6/1
期刊
Environment international
卷号
127
页码范围
601-614
出版商
Pergamon
简介
Background
Long-term exposure to fine particulate matter (PM2.5) can causally contribute to progression of atherosclerosis, risk of ischemic heart disease and death, but the underlying mechanism is little known. Since DNA methylation impacts the process of heart disease, it might be useful in exploring potential mechanistic pathways linking PM2.5 exposure and heart disease.
Objectives
Here, we investigated the PM2.5-induced ADRB2 hypermethylation and the involving epigenetic mechanism of PM2.5-induced cardiomyocytes apoptosis and cardiac dysfunction.
Methods and results
In vitro, PM2.5 markedly augmented cardiotoxicity including oxidative damage and apoptosis in cardiomyocytes AC16 as well as epigenetic alteration. DNA methylation profiling revealed a significant gene-ADRB2 was involved in the cardiac relative GO and KEGG pathways. Methylation chip and Bisulfite Sequencing PCR (BSP) both …
学术搜索中的文章
X Yang, T Zhao, L Feng, Y Shi, J Jiang, S Liang, B Sun… - Environment international, 2019