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Background Hippocampal volume reduction has been reported inconsistently in people with major depression. Aims To evaluate the interrelationships between hippocampal volumes, memory and key clinical, vascular and genetic risk factors. Method Totals of 66 people with depression and 20 control participants underwent magnetic resonance imaging and clinical assessment. Measures of depression severity, psychomotor retardation, verbal and visual memory and vascular and specific genetic risk factors were collected. Results Reduced hippocampal volumes occurred in older people with depression, those with both early-onset and late-onset disorders and those with the melancholic subtype. Reduced hippocampal volumes were associated with deficits in visual and verbal memory performance. Conclusions Although reduced hippocampal volumes are most pronounced in late-onset depression, older people …