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Spatial filters are used for increasing selectivity in surface EMG signal detection. The study investigated the importance of the description of the volume conductor to the inference of conclusions on comparing filter selectivity, from simulation analyses. A cylindrical multi-layer description of the volume conductor was used for the simulation analysis. Different anatomies were analysed with this model, and results on filter selectivity were compared. The longitudinal single (LSD), double (LDD) and normal double differential (Laplacian, NDD) filters were investigated. Largely different conclusions could be drawn when comparing filter selectivity resulting from simulations with different volume conductor models. A filter that performed best with a particular anatomy could be the poorest with another anatomy. With a bone-muscle model and superficial fibres, the ratio between peak-to-peak values of the propagating …