作者
Michael I Jensen-Seaman, Terrence S Furey, Bret A Payseur, Yontao Lu, Krishna M Roskin, Chin-Fu Chen, Michael A Thomas, David Haussler, Howard J Jacob
发表日期
2004/4/1
期刊
Genome research
卷号
14
期号
4
页码范围
528-538
出版商
Cold Spring Harbor Lab
简介
Levels of recombination vary among species, among chromosomes within species, and among regions within chromosomes in mammals. This heterogeneity may affect levels of diversity, efficiency of selection, and genome composition, as well as have practical consequences for the genetic mapping of traits. We compared the genetic maps to the genome sequence assemblies of rat, mouse, and human to estimate local recombination rates across these genomes. Humans have greater overall levels of recombination, as well as greater variance. In rat and mouse, the size of the chromosome and proximity to telomere have less effect on local recombination rate than in human. At the chromosome level, rat and mouse X chromosomes have the lowest recombination rates, whereas human chromosome X does not show the same pattern. In all species, local recombination rate is significantly correlated with several …
引用总数
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MI Jensen-Seaman, TS Furey, BA Payseur, Y Lu… - Genome research, 2004