作者
Ancha Baranova, Shobha J Gowder, Karen Schlauch, Hazem Elariny, Rochelle Collantes, Arian Afendy, Janus P Ong, Zachary Goodman, Vikas Chandhoke, Zobair M Younossi
发表日期
2006/9
期刊
Obesity surgery
卷号
16
期号
9
页码范围
1118-1125
出版商
Springer-Verlag
简介
Background
Adipose tissue is an active endocrine organ that secretes a variety of metabolically important substances including adipokines. These factors affect insulin sensitivity and may represent a link between obesity, insulin resistance, type 2 diabetes (DM), and nonalcoholic fatty liver disease (NAFLD). This study uses real-time polymerase chain reaction (PCR) quantification of mRNAs encoding adiponectin, leptin, and resistin on snap-frozen samples of intra-abdominal adipose tissue of morbidly obese patients undergoing bariatric surgery.
Methods
Morbidly obese patients undergoing bariatric surgery were studied. Patients were classified into two groups: Group A (with insulin resistance) (N=11; glucose 149.84 ± 40.56 mg/dL; serum insulin 8.28 ± 3.52 μU/mL), and Group B (without insulin resistance) (N=10; glucose 102.2 ± 8.43 mg/dL; serum insulin 3.431 ± 1.162 μU/mL).
Results
Adiponectin mRNA in intra …
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