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SIR-On July 28, 1995, the timely public release of the complete DNA sequence of Haemophilus influenzae Rd made the world of biology richer, in one day, by 1,830,137 characters of genetic information encoding a complete bacterial construction kit of 1,743 predicted protein genes'. While marveling at the advances in sequencing technology one wonders how biologists will cope with the onslaught of data from this and other genome projects. To illustrate recent advances in informatics technology, we have analyzed the open reading frames of H. influenzae with the aim of adding as much biological knowledge as possible to each predicted protein sequence. The computer runs were completed in three days using the GeneQuiz software system2 which identifies likely protein functions from amino acid sequence information in a completely automated fashion. This resulted in a new set of 148 putative protein functions …