作者
Mark A Peterzan, William T Clarke, Craig A Lygate, Hannah A Lake, Justin YC Lau, Jack J Miller, Errin Johnson, Jennifer J Rayner, Moritz J Hundertmark, Rana Sayeed, Mario Petrou, George Krasopoulos, Vivek Srivastava, Stefan Neubauer, Christopher T Rodgers, Oliver J Rider
发表日期
2020/6/16
期刊
Circulation
卷号
141
期号
24
页码范围
1971-1985
出版商
Lippincott Williams & Wilkins
简介
Background
Why some but not all patients with severe aortic stenosis (SevAS) develop otherwise unexplained reduced systolic function is unclear. We investigate the hypothesis that reduced creatine kinase (CK) capacity and flux is associated with this transition.
Methods
We recruited 102 participants to 5 groups: moderate aortic stenosis (ModAS) (n=13), SevAS, left ventricular (LV) ejection fraction ≥55% (SevAS-preserved ejection fraction, n=37), SevAS, LV ejection fraction <55% (SevAS-reduced ejection fraction, n=15), healthy volunteers with nonhypertrophied hearts with normal systolic function (normal healthy volunteer, n=30), and patients with nonhypertrophied, non–pressure-loaded hearts with normal systolic function undergoing cardiac surgery and donating LV biopsy (non–pressure-loaded heart biopsy, n=7). All underwent cardiac magnetic resonance imaging and 31P magnetic resonance …
学术搜索中的文章
MA Peterzan, WT Clarke, CA Lygate, HA Lake… - Circulation, 2020