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Peripheral vascular disease (PVD) is a highly prevalent and progressive atherosclerotic disease of the lower extremities that is associated with claudication, nonhealing ulcers, major amputations, and death. 1 In addition to lower extremity complications, PVD is also associated with high rates of myocardial infarction and stroke. 2 In a study of Medicare patients, annual costs for PVD-related treatment totaled $4.37 billion. 3 Because of the onset of atherosclerosis-induced tissue ischemia and necrosis, many patients with PVD require lower extremity revascularization using endovascular procedures or surgical bypass. 4 Nonsurgical options have traditionally been limited to endovascular procedures that have resulted in high rates of stenosis, but recent developments in drug-eluting balloons 5 and stents, 6, 7 which possess antiproliferative agents, have increased the opportunities for novel therapeutics. In addition to …