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Peripherally derived CD11b⁺ myeloid dendritic cells (mDCs), plasmacytoid DCs, CD8α⁺ DCs and macrophages accumulate in the central nervous system during relapsing experimental autoimmune encephalomyelitis (EAE). During acute relapsing EAE induced by a proteolipid protein peptide of amino acids 178–191, transgenic T cells (139TCR cells) specific for the relapse epitope consisting of proteolipid protein peptide amino acids 139–151 clustered with mDCs in the central nervous system, were activated and differentiated into T helper cells producing interleukin 17 (T_H-17 cells). CNS mDCs presented endogenously acquired peptide, driving the proliferation of and production of interleukin 17 by naive 139TCR cells in vitro and in vivo. The mDCs uniquely biased T_H-17 and not T_H1 differentiation, correlating with their enhanced expression of transforming growth factor-β1 and interleukins 6 and 23 …