作者
Jan D Huizinga, Ji-Hong Chen, Yong Fang Zhu, Andrew Pawelka, Ryan J McGinn, Berj L Bardakjian, Sean P Parsons, Wolfgang A Kunze, Richard You Wu, Premysl Bercik, Amir Khoshdel, Sifeng Chen, Sheng Yin, Qian Zhang, Yuanjie Yu, Qingmin Gao, Kongling Li, Xinghai Hu, Natalia Zarate, Phillip Collins, Marc Pistilli, Junling Ma, Ruixue Zhang, David Chen
发表日期
2014/2/24
期刊
Nature communications
卷号
5
期号
1
页码范围
3326
出版商
Nature Publishing Group UK
简介
The segmentation motor activity of the gut that facilitates absorption of nutrients was first described in the late 19th century, but the fundamental mechanisms underlying it remain poorly understood. The dominant theory suggests alternate excitation and inhibition from the enteric nervous system. Here we demonstrate that typical segmentation can occur after total nerve blockade. The segmentation motor pattern emerges when the amplitude of the dominant pacemaker, the slow wave generated by interstitial cells of Cajal associated with the myenteric plexus (ICC-MP), is modulated by the phase of induced lower frequency rhythmic transient depolarizations, generated by ICC associated with the deep muscular plexus (ICC-DMP), resulting in a waxing and waning of the amplitude of the slow wave and a rhythmic checkered pattern of segmentation motor activity. Phase–amplitude modulation of the slow waves points to …
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JD Huizinga, JH Chen, Y Fang Zhu, A Pawelka… - Nature communications, 2014