作者
David Conen, Nicolas Rodondi, Andreas Müller, Juerg H Beer, Peter Ammann, Giorgio Moschovitis, Angelo Auricchio, Daniel Hayoz, Richard Kobza, Dipen Shah, Jan Novak, Jürg Schläpfer, Marcello Di Valentino, Stefanie Aeschbacher, Steffen Blum, Pascal Meyre, Christian Sticherling, Leo H Bonati, Georg Ehret, Elisavet Moutzouri, Urs Fischer, Andreas U Monsch, Christoph Stippich, Jens Wuerfel, Tim Sinnecker, Michael Coslovsky, Matthias Schwenkglenks, Michael Kühne, Stefan Osswald, Swiss-AF Study Investigators
发表日期
2019/3/12
期刊
Journal of the American College of Cardiology
卷号
73
期号
9
页码范围
989-999
出版商
American College of Cardiology Foundation
简介
Background
Patients with atrial fibrillation (AF) have an increased risk of cognitive decline, potentially resulting from clinically unrecognized vascular brain lesions.
Objectives
This study sought to assess the relationships between cognitive function and vascular brain lesions in patients with AF.
Methods
Patients with known AF were enrolled in a multicenter study in Switzerland. Brain magnetic resonance imaging (MRI) and cognitive testing using the Montreal Cognitive Assessment (MoCA) were performed in all participants. Large noncortical or cortical infarcts (LNCCIs), small noncortical infarcts (SNCIs), microbleeds, and white matter lesions were quantified by a central core laboratory. Clinically silent infarcts were defined as infarcts on brain MRI in patients without a clinical history of stroke or transient ischemic attack.
Results
The study included 1,737 patients with a mean age of 73 ± 8 years (28% women, 90% taking …
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D Conen, N Rodondi, A Müller, JH Beer, P Ammann… - Journal of the American College of Cardiology, 2019