作者
Alexander Adjei, Vida Kukula, Clement Tetteh Narh, Selase Odopey, Emmanuel Arthur, Gabriel Odonkor, Michael Matey Mensah, Piero Olliaro, Philip Horgan, Sabine Dittrich, Catrin E Moore, Olawale Salami, Elizabeth Awini, Juvenal Nkeramahame, John Williams, Rita Baiden
发表日期
2023/7/15
期刊
Clinical Infectious Diseases
卷号
77
期号
Supplement_2
页码范围
S145-S155
出版商
Oxford University Press
简介
Background
Inappropriate antibiotic prescriptions are a known driver of antimicrobial resistance in settings with limited diagnostic capacity. This study aimed to assess the impact of diagnostic algorithms incorporating rapid diagnostic tests on clinical outcomes and antibiotic prescriptions compared with standard-of-care practices, of acute febrile illness cases at outpatient clinics in Shai-Osudoku and Prampram districts in Ghana.
Methods
This was an open-label, centrally randomized controlled trial in 4 health facilities. Participants aged 6 months to <18 years of both sexes with acute febrile illness were randomized to receive a package of interventions to guide antibiotic prescriptions or standard care. Clinical outcomes were assessed on day 7.
Results
In total, 1512 patients were randomized to either the intervention (n = 761) or control (n = 751) group …
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A Adjei, V Kukula, CT Narh, S Odopey, E Arthur… - Clinical Infectious Diseases, 2023