作者
Francois Kiemde, Daniel Valia, Berenger Kabore, Toussaint Rouamba, Alima Nadine Kone, Seydou Sawadogo, Adelaide Compaore, Olawale Salami, Philip Horgan, Catrin E Moore, Sabine Dittrich, Juvenal Nkeramahame, Piero Olliaro, Halidou Tinto
发表日期
2023/7/15
期刊
Clinical Infectious Diseases
卷号
77
期号
Supplement_2
页码范围
S134-S144
出版商
Oxford University Press
简介
Background
Low- and middle-income countries face significant challenges in differentiating bacterial from viral causes of febrile illnesses, leading to inappropriate use of antibiotics. This trial aimed to evaluate the impact of an intervention package comprising diagnostic tests, a diagnostic algorithm, and a training-and-communication package on antibiotic prescriptions and clinical outcomes.
Methods
Patients aged 6 months to 18 years with fever or history of fever within the past 7 days with no focus, or a suspected respiratory tract infection, arriving at 2 health facilities were randomized to either the intervention package or standard practice. The primary outcomes were the proportions of patients who recovered at day 7 (D7) and patients prescribed antibiotics at day 0.
Results
Of 1718 patients randomized, 1681 (97.8%; intervention: 844; control: 837 …
学术搜索中的文章
F Kiemde, D Valia, B Kabore, T Rouamba, AN Kone… - Clinical Infectious Diseases, 2023