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objectives Hypothyroidism is associated with a number of abnormalities in lipoprotein metabolism. Although alterations in neutral lipid exchanges among plasma lipoproteins might be one characteristic feature of hypothyroidism, a few human studies of cholesteryl ester transfer protein (CETP) activity have led to heterogeneous and fragmentary observations. The aim of the present study was to analyse the influence of short‐term hypothyroidism on CETP activity, as well as on the structure and composition of lipoproteins.

patients, design and measurements Sixty‐six thyroidectomized patients were withdrawn from L‐thyroxine (L‐T₄) treatment for 5 weeks. Subsequently, L‐T₄ therapy was reinstated for 2 months and patients were compared to 61 matched normolipidaemic controls. Serum CETP activity and mass concentration, serum lipids, apolipoproteins and lipoprotein size distribution were determined in the three …