作者
Y Slinin, ML Paudel, BC Taylor, HA Fink, A Ishani, MT Canales, K Yaffe, E Barrett-Connor, ES Orwoll, JM Shikany, ES Leblanc, JA Cauley, KE Ensrud
发表日期
2010/1/5
期刊
Neurology
卷号
74
期号
1
页码范围
33-41
出版商
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
简介
Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline.
Methods: We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function.
Results: In a model adjusted for age, season, and site, men with lower 25(OH)D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81–4.19 for quartile [Q] 1; 1.41, 0.61–3.28 for Q2; and 1.18, 0.50–2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR …
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Y Slinin, ML Paudel, BC Taylor, HA Fink, A Ishani… - Neurology, 2010
