作者
Ahmed A Moustafa, Srinivasa Chakravarthy, Joseph R Phillips, Jacob J Crouse, Ankur Gupta, Michael J Frank, Julie M Hall, Marjan Jahanshahi
发表日期
2016/7/1
来源
Reviews in the Neurosciences
卷号
27
期号
5
页码范围
535-548
出版商
De Gruyter
简介
Parkinson’s disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how …
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AA Moustafa, S Chakravarthy, JR Phillips, JJ Crouse… - Reviews in the Neurosciences, 2016