作者
Georgios Antonios Margonis, Kazunari Sasaki, Sepideh Gholami, Yuhree Kim, Nikolaos Andreatos, Neda Rezaee, Amar Deshwar, Stefan Buettner, Peter J Allen, T Peter Kingham, Timothy M Pawlik, Jin He, John L Cameron, William R Jarnagin, Christopher L Wolfgang, Michael I D'Angelica, Matthew J Weiss
发表日期
2018/8
期刊
Journal of British Surgery
卷号
105
期号
9
页码范围
1210-1220
出版商
Oxford University Press
简介
Background
This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS.
Methods
A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score. The score was compared with the current standard (Fong score) and validated in an external cohort of patients from the Memorial Sloan Kettering Cancer Center (MSKCC).
Results
Six preoperative predictors of worse OS were identified on multivariable Cox regression analysis in the JHH cohort (502 patients). The GAME score was calculated by …
学术搜索中的文章
GA Margonis, K Sasaki, S Gholami, Y Kim, N Andreatos… - Journal of British Surgery, 2018