作者
Georgios Antonios Margonis, Stefan Buettner, Nikolaos Andreatos, Doris Wagner, Kazunari Sasaki, Carlotta Barbon, Andrea Beer, Carsten Kamphues, Inger Marie Løes, Jin He, Timothy M Pawlik, Klaus Kaczirek, George Poultsides, Per Eystein Lønning, John L Cameron, Hans Joerg Mischinger, Federico N Aucejo, Martin E Kreis, Christopher L Wolfgang, Matthew J Weiss
发表日期
2019/6/1
期刊
Annals of surgery
卷号
269
期号
6
页码范围
1129-1137
出版商
LWW
简介
Objective:
To evaluate the changing impact of genetic and clinicopathologic factors on conditional overall survival (CS) over time in patients with resectable colorectal liver metastasis.
Background:
CS estimates account for the changing likelihood of survival over time and may reveal the changing impact of prognostic factors as time accrues from the date of surgery.
Methods:
CS analysis was performed in 1099 patients of an international, multi-institutional cohort. Three-year CS (CS3) estimates at the “xth” year after surgery were calculated as follows: CS3= CS (x+ 3)/CS (x). The standardized difference (d) between CS3 rates was used to estimate the changing prognostic power of selected variables over time. A d< 0.1 indicated very small differences between groups, 0.1≤ d< 0.3 indicated small differences, 0.3≤ d< 0.5 indicated moderate differences, and d≥ 0.5 indicated strong differences.
Results:
According to OS …
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