作者
Sonya Craig, Ilias Kylintireas, Malcolm Kohler, Debby Nicoll, Daniel J Bratton, Andrew J Nunn, Paul Leeson, Stefan Neubauer, John R Stradling
发表日期
2015/9/15
期刊
Journal of Clinical Sleep Medicine
卷号
11
期号
9
页码范围
967-973
出版商
American Academy of Sleep Medicine
简介
Study Objectives
Minimally symptomatic obstructive sleep apnea (OSA) is highly prevalent, and the effects of continuous positive airway pressure (CPAP) on myocardial function in these patients are unknown. The MOSAIC randomized, controlled trial of CPAP for minimally symptomatic OSA assessed the effect of CPAP on myocardial function in a subset of patients.
Methods
Two centers taking part in the MOSAIC trial randomized 238 patients in parallel to 6 months of CPAP (120) or standard care (118). Of these, 168 patients had echocardiograms, and 68 patients had a cardiac magnetic resonance scan (CMR). A larger group (314) from 4 centers had brain natriuretic peptide (BNP) measured.
Results
Mean (SD) baseline oxygen desaturation index (ODI) and Epworth sleepiness score (ESS) were 13.5 (13.2), and 8.4 (4.0), respectively. CPAP significantly reduced ESS and ODI. Baseline LV ejection fraction (LVEF) was …
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S Craig, I Kylintireas, M Kohler, D Nicoll, DJ Bratton… - Journal of Clinical Sleep Medicine, 2015