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Stressful experiences can produce analgesia, termed stress‐induced analgesia (SIA). Meanwhile, it has been widely established that the mesolimbic dopamine pathway and nucleus accumbens (NAc) have a profound role in pain modulation. In this study, we examined the role of accumbal dopamine receptors in antinociception caused by forced swim stress (FSS) in order to understand more about the function of these receptors within the NAc in FSS‐induced analgesia.

Stereotaxic surgery was unilaterally performed on adult male Wistar rats weighing 230–250 g (some on the left and some on the right side of the midline). Two supergroups were microinjected into the NAc with a D1‐like dopamine receptor antagonist, SCH‐23390, at doses of 0.25, 1 and 4 μg/0.5 μl saline per rat or Sulpiride as a D2‐like dopamine receptor antagonist at the same doses [0.25, 1 and 4 μg/0.5 μl dimethyl …