作者
Christa Buechler, Mirko Ritter, Evelyn Orsó, Thomas Langmann, Jochen Klucken, Gerd Schmitz
发表日期
2000/1
期刊
Journal of leukocyte biology
卷号
67
期号
1
页码范围
97-103
简介
CD163, also referred to as M130, a member of the scavenger receptor cysteine‐rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bight CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up‐regulated during macrophage colony‐stimulating factor (M‐CSF)‐dependent phagocytic differentiation of human blood monocytes. In contrast, monocytic cells treated with GM‐CSF and interleukin‐4 (IL‐4) for dendritic differentiation down‐regulate this antigen. CD163 expression is also suppressed by proinflammatory mediators like lipopolysaccharide (LPS), interferon‐γ (IFN‐γ), and tumor necrosis factor α, whereas IL‐6 and the antiinflammatory cytokine interleukin‐10 (IL‐10) strongly up‐regulate CD163 mRNA in monocytes and macrophages. The effects of the …
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C Buechler, M Ritter, E Orsó, T Langmann, J Klucken… - Journal of leukocyte biology, 2000