作者
Thomas Langmann, Jochen Klucken, Markus Reil, Gerhard Liebisch, Marie-Françoise Luciani, Giovanna Chimini, Wolfgang E Kaminski, Gerd Schmitz
发表日期
1999/4/2
期刊
Biochemical and biophysical research communications
卷号
257
期号
1
页码范围
29-33
出版商
Academic Press
简介
We have cloned the full-length cDNA for the human ATP binding cassette transporter 1 (hABC1). The 6603-bp open reading frame encodes a polypeptide of 2201 amino acids resulting in a deduced molecular weight of 220 kDa. The hABC1 cDNA is highly homologous (62%) to the human rim ABC transporter (ABCR). hABC1 is expressed in a variety of human tissues with highest expression levels found in placenta, liver, lung, adrenal glands, and fetal tissues. We demonstrate that the hABC1 expression is induced during differentiation of human monocytes into macrophagesin vitro.In macrophages, both the hABC1 mRNA and protein expression are upregulated in the presence of acetylated low-density lipoprotein (AcLDL). The AcLDL-induced increase in hABC1 expression is reversed by cholesterol depletion mediated by the addition of high-density lipoprotein (HDL3). Our data, demonstrating sterol-dependent …
引用总数
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T Langmann, J Klucken, M Reil, G Liebisch, MF Luciani… - Biochemical and biophysical research communications, 1999