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Some cases of T‐cell acute lymphoblastic leukaemia (ALL) express markers found in natural‐killer (NK) cells, such as CD56 and CD16. Out of 84 T‐cell ALL cases diagnosed at our Institution, CD56 and/or CD16 was detected in 24 (28·5%), which we designated T/NK‐ALL group. Clinical features, laboratory characteristics, survival and expression of cytotoxic molecules were compared in T/NK‐ALL and T‐ALL patients. Significant differences were observed regarding age (24·9 vs. 16·4 years in T/NK‐ALL and T‐ALL, respectively, P = 0·006) and platelet counts (177 × 10⁹/l vs. 75 × 10⁹/l in T/NK‐ALL and T‐ALL, respectively, P = 0·03). Immunophenotypic analysis demonstrated that CD34, CD45RA and CD33 were more expressed in T/NK‐ALL patients, whereas CD8 and terminal deoxynucleotidyl transferase were more expressed in T‐ALL patients (P < 0·05). The mean overall survival (863 vs. 1869 d …