作者
Mohammad Parvez, Lehlohonolo Benedict Qhanya, Ntsane Trevor Mthakathi, Ipeleng Kopano Rosinah Kgosiemang, Hans Denis Bamal, Nataraj Sekhar Pagadala, Ting Xie, Haoran Yang, Hengye Chen, Chrispian William Theron, Richie Monyaki, Seiso Caiphus Raselemane, Vuyani Salewe, Bogadi Lorato Mongale, Retshedisitswe Godfrey Matowane, Sara Mohamed Hasaan Abdalla, Wool Isaac Booi, Mari Van Wyk, Dedré Olivier, Charlotte E Boucher, David R Nelson, Jack A Tuszynski, Jonathan Michael Blackburn, Jae-Hyuk Yu, Samson Sitheni Mashele, Wanping Chen, Khajamohiddin Syed
发表日期
2016/9/12
期刊
Scientific reports
卷号
6
期号
1
页码范围
33099
出版商
Nature Publishing Group UK
简介
Since the initial identification of cytochrome P450 monooxygenases (CYPs/P450s), great progress has been made in understanding their structure-function relationship, diversity and application in producing compounds beneficial to humans. However, the molecular evolution of P450s in terms of their dynamics both at protein and DNA levels and functional conservation across kingdoms still needs investigation. In this study, we analyzed 17 598 P450s belonging to 113 P450 families (bacteria −42; fungi −19; plant −28; animal −22; plant and animal −1 and common P450 family −1) and found highly conserved and rapidly evolving P450 families. Results suggested that bacterial P450s, particularly P450s belonging to mycobacteria, are highly conserved both at protein and DNA levels. Mycobacteria possess the highest P450 diversity percentage compared to other microbes and have a high coverage of P450s (≥1 …
学术搜索中的文章
M Parvez, LB Qhanya, NT Mthakathi, IKR Kgosiemang… - Scientific reports, 2016