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In modern stem cell therapy, stem cells preservation is one of the major challenges. The present study aims to develop an advanced desiccation technique for the preservation of mesenchymal stem cells. Cryopreservation of human mesenchymal stem cells (MSCs) is one of the options for its long-term storage. The established techniques of preserving MSCs using cryopreservation aims to preserve cells at ultra-low temperatures using either liquid nitrogen or a deep freezer. However, limitations include cross-contamination, regular maintenance, the requirement of continuous liquid nitrogen supply, and electricity cost. A new technique of storing dried samples at ambient temperature has been developed utilizing desiccation. In this study, we desiccated the mesenchymal stem cells using a low-cost, power-free 3D printed whirligig model. It is an improved and effective method for preserving many different types of …