作者
Ashlesh K Murthy, James P Chambers, Patricia A Meier, Guangming Zhong, Bernard P Arulanandam
发表日期
2007/2
期刊
Infection and immunity
卷号
75
期号
2
页码范围
666-676
出版商
American Society for Microbiology
简介
There is currently no licensed vaccine against Chlamydia trachomatis, the leading cause of sexually transmitted bacterial disease worldwide. Conventional vaccination attempts using surface-exposed chlamydial antigens have achieved only partial success. We have employed a novel vaccination strategy using a secreted protein, chlamydial protease-like activity factor (CPAF), which has been shown to degrade host major histocompatibility complex transcription factors and keratin-8 and therefore may allow immune evasion and establishment of a productive infection. Intranasal immunization using recombinant CPAF (rCPAF) plus interleukin-12 (IL-12) (rCPAF+IL-12 immunization) was used to assess the protective immunity against genital Chlamydia muridarum infection in BALB/c mice. rCPAF+IL-12 immunization induced robust gamma interferon (IFN-γ) production and minimal IL-4 production by splenocytes …
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AK Murthy, JP Chambers, PA Meier, G Zhong… - Infection and immunity, 2007