作者
PA Thompson, DE Wright, CE Counsell, J Zajicek
发表日期
2012/5
期刊
International Psychogeriatrics
卷号
24
期号
5
页码范围
689
简介
Background
The social and economic burden of Alzheimer's disease (AD) and its increasing prevalence has led to much work on new treatment strategies and clinical trials. The search for surrogate markers of disease progression continues but traditional parallel group trial designs that use well-established, but often insensitive, clinical outcome measures predominate.
Methods
We performed a systematic search across the Cochrane Library and PubMed abstracts published between January 2004 and August 2009. Information regarding the clinical trial methodology, outcome measures, intervention type and primary statistical analysis techniques was extracted and categorized, according to a standard protocol.
Results
We identified 149 papers describing results from clinical trials in AD containing sufficient detail for our purposes. The largest proportion (38%) presented results of trials based on tests of cognition as …
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PA Thompson, DE Wright, CE Counsell, J Zajicek - International psychogeriatrics, 2012