作者
Oliver J Liakopoulos, Yeong-Hoon Choi, Elmar W Kuhn, Thorsten Wittwer, Michal Borys, Navid Madershahian, Gernot Wassmer, Thorsten Wahlers
发表日期
2009/9/1
来源
The Journal of thoracic and cardiovascular surgery
卷号
138
期号
3
页码范围
678-686. e1
出版商
Mosby
简介
OBJECTIVE
To determine the strength of evidence of preoperative statin therapy for prevention of atrial fibrillation after cardiac surgery.
METHODS
A meta-analysis was performed of randomized controlled trials and observational trials reporting the impact of preoperative statin therapy on the incidence of any type and new-onset atrial fibrillation after cardiac surgery. Unadjusted and adjusted treatment effects (odds ratio, 95% confidence intervals) were pooled using a random-effects model, and publication bias was assessed.
RESULTS
Thirteen studies were identified (3 randomized controlled trials, 10 observational trials) that reported the incidence of postoperative atrial fibrillation in 17,643 patients having cardiac surgery with (n = 10,304; 58%) or without (n = 7339; 42%) preoperative statin use. New-onset atrial fibrillation was reported in a total of 7855 patients. Postoperative incidence rates for any or new-onset …
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OJ Liakopoulos, YH Choi, EW Kuhn, T Wittwer, M Borys… - The Journal of thoracic and cardiovascular surgery, 2009