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This review by a multidisciplinary team maps key components and emerging connections within the intellectual landscape of agroecology. We attempt to extend and preview agroecology as a discipline in which agriculture can be conceptualized within the context of global change and studied as a coupled system involving a wide range of social and natural processes. This intrinsic coupling, combined with powerful emerging drivers of change, presents challenges for the practice of agroecology and agriculture itself, as well as providing the framework for some of the most innovative research areas and the greatest potential for innovation for a sustainable future in agriculture. The objective of this review is to identify forward-looking scientific questions to enhance the relevance of agroecology for the key challenges of mitigating environmental impacts of agriculture while dramatically increasing global food production …