作者
Robert Brownell, Teng Moua, Travis S Henry, Brett M Elicker, Darin White, Eric Vittinghoff, Kirk D Jones, Anatoly Urisman, Carlos Aravena, Kerri A Johannson, Jeffrey A Golden, Talmadge E King, Paul J Wolters, Harold R Collard, Brett Ley
发表日期
2017/5/1
期刊
Thorax
卷号
72
期号
5
页码范围
424-429
出版商
BMJ Publishing Group Ltd
简介
Background
Recent studies have suggested that non-definitive patterns on high-resolution CT (HRCT) scan provide sufficient diagnostic specificity to forgo surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis (IPF). The objective of this study was to determine test characteristics of non-definitive HRCT patterns for identifying histopathological usual interstitial pneumonia (UIP).
Methods
Patients with biopsy-proven interstitial lung disease (ILD) and non-definitive HRCT scans were identified from two academic ILD centres. Test characteristics for HRCT patterns as predictors of UIP on surgical lung biopsy were derived and validated in independent cohorts.
Results
In the derivation cohort, 64/385 (17%) had possible UIP pattern on HRCT; 321/385 (83%) had inconsistent with UIP pattern. 113/385 (29%) patients had histopathological UIP pattern in the derivation cohort. Possible UIP pattern had a specificity …
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R Brownell, T Moua, TS Henry, BM Elicker, D White… - Thorax, 2017