作者
Renata Franzon, Lizandra F Guimarães, Camila E Magalhães, Alex N Haas, Fernando B Araujo, G Carpenter, E Cotroneo, R Moazzez, M Rojas-Serrano, N Donaldson, R Austin, L Zaidel, D Bartlett, G Proctor, Irene Dige, Lene Grønkjær, Bente Nyvad, FL Brighenti, MJ Salvador, Alberto Carlos Botazzo Delbem, Ádina Cleia Bottazzo Delbem, MAC Oliveira, CP Soares, LSF Freitas, CY Koga-Ito, Alexandre R Vieira, Adriana Modesto, Mary L Marazita, Sisko Honkala, Riina Runnel, Mare Saag, Jana Olak, Rita Nõmmela, Silvia Russak, Pirkko-Liisa Mäkinen, Tero Vahlberg, Gwen Falony, Kauko Mäkinen, Eino Honkala, Lidija Nemeth, Ksenija Cankar, Franci Bajd, Jernej Vidmar, Igor Serša, Michael F Lorber, Amy M Smith Slep, Richard E Heyman, Walter A Bretz, Joanna Krzyżostaniak, Anna Surdacka, Tomasz Kulczyk, Marta Dyszkiewicz-Konwińska, Magdalena Owecka, D Belstrøm, N-E Fiehn, CH Nielsen, P Holmstrup, N Kirkby, V Klepac-Ceraj, BJ Paster, S Twetman, Satz Mengensatzproduktion, Werner Druck, AG Medien
发表日期
2014
期刊
Caries Research
卷号
48
期号
5
页码范围
384-450
出版商
Karger Publishers
简介
To evaluate (i) the effect of Photodynamic Antimicrobial Chemotherapy (PACT) using curcumin (C) and a blue LED (BL) on S. mutans (SM) mature biofilm in comparison to 0.12% chlorhexidine (CHX) and (ii) PACT optimization using a novel white light (WL) and C on planktonic SM.(i) PACT was performed using BL (48 J. cm2, 3′ 33′′) combined with C (2.5 mM). SM biofilms were formed on saliva-coated hydroxyapatite discs in batch culture, replacing the medium daily for five days. Treatments were C+ BL+(PACT); C only; BL only; CHX (60′′) or no treatment. Assays: variable pressure scanning electron microscopy, confocal laser scanning microscopy and microbial viability (colony-forming units–CFU/mg of biofilm dry weight).(ii) SM was adjusted at 1× 106 cells/ml in PBS and the treatments were performed using WL (42 J. cm2, 12′′) with C (0.75 μM) using the same design of (i). The CFU/mg was …
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R Franzon, LF Guimarães, CE Magalhães, AN Haas… - Caries Research, 2014