作者
Ajai Chari, Dan T Vogl, Maria Gavriatopoulou, Ajay K Nooka, Andrew J Yee, Carol A Huff, Philippe Moreau, David Dingli, Craig Cole, Sagar Lonial, Meletios Dimopoulos, A Keith Stewart, Joshua Richter, Ravi Vij, Sascha Tuchman, Marc S Raab, Katja C Weisel, Michel Delforge, Robert F Cornell, David Kaminetzky, James E Hoffman, Luciano J Costa, Terri L Parker, Moshe Levy, Martin Schreder, Nathalie Meuleman, Laurent Frenzel, Mohamad Mohty, Sylvain Choquet, Gary Schiller, Raymond L Comenzo, Monika Engelhardt, Thomas Illmer, Philip Vlummens, Chantal Doyen, Thierry Facon, Lionel Karlin, Aurore Perrot, Klaus Podar, Michael G Kauffman, Sharon Shacham, Lingling Li, Shijie Tang, Carla Picklesimer, Jean-Richard Saint-Martin, Marsha Crochiere, Hua Chang, Samir Parekh, Yosef Landesman, Jatin Shah, Paul G Richardson, Sundar Jagannath
发表日期
2019/8/22
期刊
New England Journal of Medicine
卷号
381
期号
8
页码范围
727-738
出版商
Massachusetts Medical Society
简介
Background
Selinexor, a selective inhibitor of nuclear export compound that blocks exportin 1 (XPO1) and forces nuclear accumulation and activation of tumor suppressor proteins, inhibits nuclear factor κB, and reduces oncoprotein messenger RNA translation, is a potential novel treatment for myeloma that is refractory to current therapeutic options.
Methods
We administered oral selinexor (80 mg) plus dexamethasone (20 mg) twice weekly to patients with myeloma who had previous exposure to bortezomib, carfilzomib, lenalidomide, pomalidomide, daratumumab, and an alkylating agent and had disease refractory to at least one proteasome inhibitor, one immunomodulatory agent, and daratumumab (triple-class refractory). The primary end point was overall response, defined as a partial response or better, with response assessed by an independent review committee. Clinical benefit, defined as a minimal …
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A Chari, DT Vogl, M Gavriatopoulou, AK Nooka, AJ Yee… - New England Journal of Medicine, 2019
