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Nowadays, the development of e‐health monitoring devices is getting more demand for remote health applications. In addition, cardiovascular diseases is considered the most chronic disease in recent years. So, this requires a fast diagnosis and therapy to clear this issue and requires an information transformation from the patient to the distant hospital. But, it faces many challenges like more energy consumption, data security, storage, and transmission. In addition, the electrocardiogram (ECG) data must be processed in real‐time, and the information must have high predictability and lossless compression. So, in this article, an enhanced set partitioning in hierarchical tree decoder with deep belief neural network is developed for ECG compression. Due to an inappropriate channel in telemedicine applications, the ECG signals transmitted through a wireless network are affected by noise. So, fast normalized least …