作者
Marjorie Solomon, Michael J Frank, J Daniel Ragland, Anne C Smith, Tara A Niendam, Tyler A Lesh, David S Grayson, Jonathan S Beck, John C Matter, Cameron S Carter
发表日期
2015/2/1
期刊
American Journal of Psychiatry
卷号
172
期号
2
页码范围
173-181
出版商
American Psychiatric Association
简介
Objective
Impairments in learning are central to autism spectrum disorders. The authors investigated the cognitive and neural basis of these deficits in young adults with autism spectrum disorders using a well-characterized probabilistic reinforcement learning paradigm.
Method
The probabilistic selection task was implemented among matched participants with autism spectrum disorders (N=22) and with typical development (N=25), aged 18–40 years, using rapid event-related functional MRI. Participants were trained to choose the correct stimulus in high-probability (AB), medium-probability (CD), and low-probability (EF) pairs, presented with valid feedback 80%, 70%, and 60% of the time, respectively. Whole-brain voxel-wise and parametric modulator analyses examined early and late learning during the stimulus and feedback epochs of the task.
Results
The groups exhibited comparable performance on medium …
学术搜索中的文章
M Solomon, MJ Frank, JD Ragland, AC Smith… - American Journal of Psychiatry, 2015