作者
Karar H Dwaich, Fadhil GY Al-Amran, Bassim IM AL-Sheibani, Hayder A Al-Aubaidy
发表日期
2016/10/15
期刊
International Journal of Cardiology
卷号
221
页码范围
977-986
出版商
Elsevier
简介
Background
Myocardial ischemia/reperfusion injury represents a clinically critical problem associated with coronary artery bypass graft surgery (CABG). The degree of oxidative stress, inflammation and apoptosis are increased during the reperfusion of the heart muscles following ischemia. The present study aims to examine the protective role of melatonin in ameliorating the degree of cardiac injury in patients undergoing bypass surgery, and whether this effect is a dose related.
Methods
A total of forty-five patients who were undergoing elective CABG in (Al-Najaf Cardiac Center, Al-Najaf, Iraq) were included in this study for the period between January, 2015 and November, 2015. Participants were randomly allocated into 3 study groups: Placebo-controlled group (C), low dose melatonin treatment group, 10 mg capsule once daily (M1) and high dose melatonin treatment group 20 mg capsule once daily (M2).
Results …
学术搜索中的文章
KH Dwaich, FGY Al-Amran, BIM Al-Sheibani… - International journal of cardiology, 2016