作者
Adam Castano, Muhammad Haq, David L Narotsky, Jeff Goldsmith, Richard L Weinberg, Rachelle Morgenstern, Ted Pozniakoff, Frederick L Ruberg, Edward J Miller, John L Berk, Angela Dispenzieri, Martha Grogan, Geoffrey Johnson, Sabahat Bokhari, Mathew S Maurer
发表日期
2016/11/1
期刊
JAMA cardiology
卷号
1
期号
8
页码范围
880-889
出版商
American Medical Association
简介
Importance
Transthyretin cardiac amyloidosis (also known as ATTR cardiac amyloidosis) is an increasingly recognized cause of heart failure with preserved ejection fraction. In single-center studies, technetium 99m pyrophosphate (Tc 99m PYP) cardiac imaging noninvasively detects ATTR cardiac amyloidosis, but the accuracy of this technique in a multicenter study and the association of Tc 99m PYP myocardial uptake with survival are unknown.
Objective
To assess Tc 99m PYP cardiac imaging as a diagnostic tool for ATTR cardiac amyloidosis and its association with survival in a multicenter study.
Design, Setting, and Participants
Retrospective cohort study performed at 3 academic specialty centers for cardiac amyloidosis in the United States in which 229 participants were evaluated for cardiac amyloidosis and also underwent Tc 99m PYP cardiac imaging. The date of analysis and final confirmation from the …
学术搜索中的文章
A Castano, M Haq, DL Narotsky, J Goldsmith… - JAMA cardiology, 2016