作者
Francesco Zanon, Enrico Baracca, Gianni Pastore, Lina Marcantoni, Chiara Fraccaro, Daniela Lanza, Claudio Picariello, Silvio Aggio, Loris Roncon, Fabio Dell’Avvocata, GianLuca Rigatelli, Domenico Pacetta, Franco Noventa, Frits W Prinzen
发表日期
2015/5/1
期刊
Heart Rhythm
卷号
12
期号
5
页码范围
975-981
出版商
Elsevier
简介
Background
Response to cardiac resynchronization therapy (CRT) remains challenging. Pacing from multiple sites of the left ventricle (LV) has shown promising results.
Objective
The purpose of this study was to systematically compare the acute hemodynamic effects of multipoint pacing (MPP) by means of a quadripolar lead with conventional biventricular (BiV) pacing.
Methods
Twenty-nine patients (23 men; mean age 72 ± 12 years; LV ejection fraction 29% ± 7%; 15 with ischemic cardiomyopathy, 17 with left bundle branch block; mean QRS 183 ± 23 ms) underwent CRT implantation. Per patient, 3.2 ± 1.2 different veins and 6.3 ± 2.4 pacing sites were tested. LV electrical delay (Q-LV) was measured at each location, along with the increase in LV dP/dtmax (maximum rate of rise of LV pressure) obtained by BiV and MPP. The effect of MPP, by means of simultaneous pacing from distal and proximal dipoles, was …
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F Zanon, E Baracca, G Pastore, L Marcantoni… - Heart Rhythm, 2015