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OBJECTIVE:

The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats.

DESIGN:

This study has a randomized controlled experimental design.

SETTING:

Healthy (n= 32) and diabetic (n= 32) rats were further divided into 2 groups of saline or paroxetine administration.

PARTICIPANTS:

Sixty-four male Sprague-Dawley rats were used in this study.

INTERVENTIONS:

Paroxetine was injected intraperitoneally every day. Full-thickness excision wounds were created with a 4-mm dermal punch on the back of all rats. The healing wound area was removed with a 6-mm dermal punch at postwounding days 1, 3, 7, and 14.

MAIN OUTCOME MEASURES:

Polymorphonuclear leukocyte, mononuclear inflammatory cell, fibroblast, and blood vessel counts and epithelialization were evaluated under light microscope.

MAIN RESULTS …