作者
Daniel F Gudbjartsson, Hilma Holm, Solveig Gretarsdottir, Gudmar Thorleifsson, G Bragi Walters, Gudmundur Thorgeirsson, Jeffrey Gulcher, Ellisiv B Mathiesen, Inger Njølstad, Audhild Nyrnes, Tom Wilsgaard, Erin M Hald, Kristian Hveem, Camilla Stoltenberg, Gayle Kucera, Tanya Stubblefield, Shannon Carter, Dan Roden, Maggie CY Ng, Larry Baum, Wing Yee So, Ka Sing Wong, Juliana CN Chan, Christian Gieger, H-Erich Wichmann, Andreas Gschwendtner, Martin Dichgans, Gregor Kuhlenbäumer, Klaus Berger, E Bernd Ringelstein, Steve Bevan, Hugh S Markus, Konstantinos Kostulas, Jan Hillert, Sigurlaug Sveinbjörnsdóttir, Einar M Valdimarsson, Maja-Lisa Løchen, Ronald CW Ma, Dawood Darbar, Augustine Kong, David O Arnar, Unnur Thorsteinsdottir, Kari Stefansson
发表日期
2009/8
期刊
Nature genetics
卷号
41
期号
8
页码范围
876-878
出版商
Nature Publishing Group US
简介
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 × 10−10). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.
引用总数
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DF Gudbjartsson, H Holm, S Gretarsdottir… - Nature genetics, 2009