作者
Solveig Gretarsdottir, Gudmar Thorleifsson, Andrei Manolescu, Unnur Styrkarsdottir, Anna Helgadottir, Andreas Gschwendtner, Konstantinos Kostulas, Gregor Kuhlenbäumer, Steve Bevan, Thorbjorg Jonsdottir, Hjordis Bjarnason, Jona Saemundsdottir, Stefan Palsson, David O Arnar, Hilma Holm, Gudmundur Thorgeirsson, Einar Mar Valdimarsson, Sigurlaug Sveinbjörnsdottir, Christian Gieger, Klaus Berger, H‐Erich Wichmann, Jan Hillert, Hugh Markus, Jeffrey Robert Gulcher, E Bernd Ringelstein, Augustine Kong, Martin Dichgans, Daniel Fannar Gudbjartsson, Unnur Thorsteinsdottir, Kari Stefansson
发表日期
2008/10
期刊
Annals of neurology
卷号
64
期号
4
页码范围
402-409
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To find sequence variants that associate with the risk for ischemic stroke (IS), we performed a genome‐wide association study.
Methods
We genotyped 1,661 Icelandic IS patients and 10,815 control subjects using the Infinium HumanHap300 chip (Illumina, San Diego, CA). A total of 310,881 single nucleotide polymorphisms (SNPs) were tested for association with IS, and the most significant signals were replicated in two large European IS sample sets (2,224 cases/2,583 control subjects). Two SNPs, rs2200733 and rs10033464, were tested further in additional European IS samples (2,327 patients and 16,760 control subjects).
Results
In the Icelandic samples and the two replication sets combined, rs2200733 associated significantly with cardioembolic stroke (CES) (odds ratio [OR], 1.54; p = 8.05 × 10−9). No other variants associated with IS or any of its subtypes. rs2200733 associated significantly with …
引用总数
学术搜索中的文章
S Gretarsdottir, G Thorleifsson, A Manolescu… - Annals of neurology, 2008