作者
Chang Liu, Helen M Ginn, Wanwisa Dejnirattisai, Piyada Supasa, Beibei Wang, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Daming Zhou, Alexander J Mentzer, Yuguang Zhao, Helen ME Duyvesteyn, César López-Camacho, Jose Slon-Campos, Thomas S Walter, Donal Skelly, Sile Ann Johnson, Thomas G Ritter, Chris Mason, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M Siqueira, Christina Dold, Nigel Temperton, Tao Dong, Andrew J Pollard, Julian C Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah C Gilbert, Tariq Malik, Miles W Carroll, Paul Klenerman, Eleanor Barnes, Susanna J Dunachie, Vicky Baillie, Natali Serafin, Zanele Ditse, Kelly Da Silva, Neil G Paterson, Mark A Williams, David R Hall, Shabir Madhi, Marta C Nunes, Philip Goulder, Elizabeth E Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I Stuart, Gavin R Screaton
发表日期
2021/8/5
期刊
Cell
卷号
184
期号
16
页码范围
4220-4236. e13
出版商
Elsevier
简介
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the United Kingdom. Here we study the ability of monoclonal antibodies and convalescent and vaccine sera to neutralize B.1.617.1 and B.1.617.2, complement this with structural analyses of Fab/receptor binding domain (RBD) complexes, and map the antigenic space of current variants. Neutralization of both viruses is reduced compared with ancestral Wuhan-related strains, but there is no evidence of widespread antibody escape as seen with B.1.351. However, B.1.351 and P.1 sera showed markedly more reduction in neutralization of B.1 …
学术搜索中的文章
C Liu, HM Ginn, W Dejnirattisai, P Supasa, B Wang… - Cell, 2021