作者
Katherine L O'Brien, Henry C Baggett, W Abdullah Brooks, Daniel R Feikin, Laura L Hammitt, Melissa M Higdon, Stephen RC Howie, Maria Deloria Knoll, Karen L Kotloff, Orin S Levine, Shabir A Madhi, David R Murdoch, Christine Prosperi, J Anthony G Scott, Qiyuan Shi, Donald M Thea, Zhenke Wu, Scott L Zeger, Peter V Adrian, Pasakorn Akarasewi, Trevor P Anderson, Martin Antonio, Juliet O Awori, Vicky L Baillie, Charatdao Bunthi, James Chipeta, Mohammod Jobayer Chisti, Jane Crawley, Andrea N DeLuca, Amanda J Driscoll, Bernard E Ebruke, Hubert P Endtz, Nicholas Fancourt, Wei Fu, Doli Goswami, Michelle J Groome, Meredith Haddix, Lokman Hossain, Yasmin Jahan, E Wangeci Kagucia, Alice Kamau, Ruth A Karron, Sidi Kazungu, Nana Kourouma, Locadiah Kuwanda, Geoffrey Kwenda, Mengying Li, Eunice M Machuka, Grant Mackenzie, Nasreen Mahomed, Susan A Maloney, Jessica L McLellan, Joanne L Mitchell, David P Moore, Susan C Morpeth, Azwifarwi Mudau, Lawrence Mwananyanda, James Mwansa, Micah Silaba Ominde, Uma Onwuchekwa, Daniel E Park, Julia Rhodes, Pongpun Sawatwong, Phil Seidenberg, Arifin Shamsul, Eric AF Simões, Seydou Sissoko, Somwe Wa Somwe, Samba O Sow, Mamadou Sylla, Boubou Tamboura, Milagritos D Tapia, Somsak Thamthitiwat, Aliou Toure, Nora L Watson, Khalequ Zaman, Syed MA Zaman
发表日期
2019/8/31
期刊
The Lancet
卷号
394
期号
10200
页码范围
757-779
出版商
Elsevier
简介
Background
Pneumonia is the leading cause of death among children younger than 5 years. In this study, we estimated causes of pneumonia in young African and Asian children, using novel analytical methods applied to clinical and microbiological findings.
Methods
We did a multi-site, international case-control study in nine study sites in seven countries: Bangladesh, The Gambia, Kenya, Mali, South Africa, Thailand, and Zambia. All sites enrolled in the study for 24 months. Cases were children aged 1–59 months admitted to hospital with severe pneumonia. Controls were age-group-matched children randomly selected from communities surrounding study sites. Nasopharyngeal and oropharyngeal (NP-OP), urine, blood, induced sputum, lung aspirate, pleural fluid, and gastric aspirates were tested with cultures, multiplex PCR, or both. Primary analyses were restricted to cases without HIV infection and with …
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KL O'Brien, HC Baggett, WA Brooks, DR Feikin… - The Lancet, 2019