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HARRIS, R. B. S., J. ZHOU, B. D. YOUNGBLOOD, G. N. SMAGIN AND D. H. RYAN. Failure to change exploration or saccharin preference in rats exposed to chronic mild stress. PHYSIOL BEHAV 63(1) 91–100, 1998.—Chronic mild stress (CMS) exposes animals to unpredictable stressors. Reduced consumption of sucrose or saccharin solutions by CMS rats has been used as a putative measure of anhedonia, typical of depression. Our objective was to determine whether saccharin consumption and preference and suppression of exploratory and rearing behaviors in the open field were reliable indicators of CMS-induced behavioral depression. In Experiment 1, male Wistar rats subjected to 6 weeks of CMS consumed significantly less food and gained less weight than controls. CMS did not effect saccharin intake, or preference, measured in a two-bottle test with water. CMS rats exposed to a novel open field showed …