作者
Marcello Tonelli, Paul Muntner, Anita Lloyd, Braden J Manns, Scott Klarenbach, Neesh Pannu, Matthew T James, Brenda R Hemmelgarn
发表日期
2012/9/1
期刊
The Lancet
卷号
380
期号
9844
页码范围
807-814
出版商
Elsevier
简介
Background
Diabetes is regarded as a coronary heart disease risk equivalent—ie, people with the disorder have a risk of coronary events similar to those with previous myocardial infarction. We assessed whether chronic kidney disease should be regarded as a coronary heart disease risk equivalent.
Methods
We studied a population-based cohort with measures of estimated glomerular filtration rate (eGFR) and proteinuria from Alberta, Canada. We used validated algorithms based on hospital admission and medical-claim data to classify participants with baseline history of myocardial infarction or diabetes and to ascertain which patients were admitted to hospital for myocardial infarction during follow-up (the primary outcome). For our primary analysis, we defined baseline chronic kidney disease as eGFR 15–59·9 mL/min per 1·73 m2 (stage 3 or 4 disease). We used Poisson regression to calculate unadjusted rates …
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