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Objective: To investigate the frequency of non-O blood groups among coronary artery disease patients.

Methodology: A cross-sectional study in the inpatient clinical areas of the Department of Medicine was conducted at a large tertiary care hospital in Islamabad, Pakistan, from June to November 2021. A non-probability sampling technique was employed and the inclusion criteria included patients aged from 25-60 years and patients of coronary artery disease with greater than or equal to 25% narrowing in any of the epicardial vessels on coronary angiography.

Results: The total sample size was 111 in the present study. 85.6% of the study population were aged between 41-60 years, while a family history of coronary artery disease was present in 45.1% of patients. The most common blood group in the study population was the O blood group (36%) followed by those with blood group B (31.5%). 64% patients had a non-O blood group. On stratification age, gender and family history of coronary artery disease was not significant.

Conclusion: von Willebrand factor had been found to be in a higher level among non-O blood groups providing a possible explanation for the increased burden of coronary artery disease in this group.