作者
Dejan Jakimovski, Jens Kuhle, Murali Ramanathan, Christian Barro, Davorka Tomic, Jesper Hagemeier, Harald Kropshofer, Niels Bergsland, David Leppert, Michael G Dwyer, Zuzanna Michalak, Ralph HB Benedict, Bianca Weinstock‐Guttman, Robert Zivadinov
发表日期
2019/9
期刊
Annals of clinical and translational neurology
卷号
6
期号
9
页码范围
1757-1770
简介
Background
Gray matter (GM) pathology is closely associated with physical and cognitive impairment in persons with multiple sclerosis (PwMS). Similarly, serum neurofilament light chain (sNfL) levels are related to MS disease activity and progression.
Objectives
To assess the cross–sectional and longitudinal associations between sNfL and MRI–derived lesion and brain volume outcomes in PwMS and age–matched healthy controls (HCs).
Materials and Methods
Forty‐seven HCs and 120 PwMS were followed over 5 years. All subjects underwent baseline and follow–up 3T MRI and sNfL examinations. Lesion volumes (LV) and global, tissue–specific and regional brain volumes were assessed. sNfL levels were analyzed using single molecule array (Simoa) assay and quantified in pg/mL. The associations between sNfL levels and MRI outcomes were investigated using regression analyses adjusted for age, sex …
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D Jakimovski, J Kuhle, M Ramanathan, C Barro… - Annals of clinical and translational neurology, 2019
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