作者
Dejan Jakimovski, Robert Zivadinov, Murali Ramanthan, Jesper Hagemeier, Bianca Weinstock-Guttman, Davorka Tomic, Harald Kropshofer, Tom A Fuchs, Christian Barro, David Leppert, Özgür Yaldizli, Jens Kuhle, Ralph HB Benedict
发表日期
2020/11
期刊
Multiple Sclerosis Journal
卷号
26
期号
13
页码范围
1670-1681
出版商
SAGE Publications
简介
Background
A limited number of studies investigated associations between serum neurofilament light chain (sNfL) and cognition in persons with multiple sclerosis (PwMS).
Objective
To assess cross-sectional and longitudinal associations between sNfL levels, clinical, and cognitive performance in PwMS and age-matched healthy controls (HCs).
Materials
One hundred twenty-seven PwMS (85 relapsing–remitting MS/42 progressive MS), 20 clinically isolated syndrome patients, and 52 HCs were followed for 5 years. sNfL levels were measured using the single-molecule array (Simoa) assay and quantified in picograms per milliliter. Expanded Disability Status Scale (EDSS), walking, and manual dexterity tests were obtained. At follow-up, Brief International Cognitive Assessment for MS (BICAMS) was utilized. Cognitively impaired (CI) status was derived using HC-based z-scores. Age-, sex-, and education-adjusted …
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