作者
Amy L Dzierba, Erik E Abel, Mitchell S Buckley, Ishaq Lat
发表日期
2014/3
来源
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
卷号
34
期号
3
页码范围
279-290
简介
Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are conditions associated with an estimated mortality of 40–50%. The use of inhaled vasodilators can help to improve oxygenation without hemodynamic effects. This article reviews relevant studies addressing the safety and efficacy of inhaled nitric oxide (iNO) and aerosolized epoprostenol (aEPO) in the treatment of life‐threatening hypoxemia associated with ARDS and ALI. In addition, the article also provides a practicable guide to the clinical application of these therapies. Nine prospective randomized controlled trials were included for iNO reporting on changes in oxygenation or clinical outcomes. Seven reports of aEPO were examined for changes in oxygenation. Based on currently available data, the use of either iNO or aEPO is safe to use in patients with ALI or ARDS to transiently improve oxygenation. No differences have been observed …
引用总数
2014201520162017201820192020202120222023202429111395810733
学术搜索中的文章